Needles, Haystacks, and Next-Generation Genetic Sequencing
نویسندگان
چکیده
منابع مشابه
Strategies and Clinical Applications of Next Generation Sequencing
Abstract DNA sequencing is one of the great valuable techniques in molecular biology, which can be used to detect the sequence of nucleotides in a DNA fragment. The high-throughput sequencing known as Next Generation Sequencing (NGS) revolutionized genomic research and molecular biology; therefore, the whole human genome can be sequenced with a low cost in several days. NGS technology is simi...
متن کاملStrategies and Clinical Applications of Next Generation Sequencing
Abstract DNA sequencing is one of the great valuable techniques in molecular biology, which can be used to detect the sequence of nucleotides in a DNA fragment. The high-throughput sequencing known as Next Generation Sequencing (NGS) revolutionized genomic research and molecular biology; therefore, the whole human genome can be sequenced with a low cost in several days. NGS technology is simi...
متن کاملBrain microarray: finding needles in molecular haystacks.
Introduction When technical advances generated novel genetic markers in the 1980s, they were combined with linkage analysis allowing thousands of genes to be profiled simultaneously (Botstein et al., 1980; Weber and May, 1989). This capability has been used to isolate the molecular causes of most monogenetic disorders of the brain. With this success as a backdrop, the persistent difficulty in i...
متن کاملNext-Generation Sequencing
Next-generation sequencing (NGS), otherwise known as deep or massively parallel sequencing, refers to the technological advances in DNA sequencing instrumentation that enable the generation of hundreds of thousands to millions of sequence reads per run. Sequencing of the human genome, which was once a >10-year endeavor by the NIH at the cost of approximately $3 billion (1), can now be done rout...
متن کاملNext-Generation Sequencing
1Human Genetics Center, The University of Texas School of Public Health, Houston, TX 77025, USA 2Departments of Biomedical Informatics and Psychiatry and Vanderbilt-Ingram Cancer Center (VICC), Vanderbilt University Medical Center, Nashville, TN 37232, USA 3Department of Genetics, The University of Georgia, Life Sciences Building, Athens, GA 30602, USA 4Human Genome Sequencing Center, Baylor Co...
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ژورنال
عنوان ژورنال: SSRN Electronic Journal
سال: 2018
ISSN: 1556-5068
DOI: 10.2139/ssrn.3183339